Malignant Fibrous Histiocytoma

Malignant fibrous histiocytoma is a condition involving a tumor of the bone or soft tissues that most often affects people between the ages of 50 and 70. In most cases, malignant fibrous histiocytoma appears in the legs or arms, but it can develop in other parts of the body. An enlarging painless mass may develop in tumors of soft tissues; fractures may occur in cases involving bone. Other common symptoms of malignant fibrous histiocytoma include fever, weight loss, and low blood sugar. Treatment options for malignant fibrous histiocytoma usually include chemotherapy and surgery.

 

What Is Malignant Fibrous Histiocytoma?

Malignant fibrous histiocytoma is a rare condition in which there is a tumor of the bone or soft tissues. Malignant fibrous histiocytoma in soft tissues is the most common soft tissue cancer that is diagnosed in older adults. Malignant fibrous histiocytoma is most often diagnosed in people between the ages of 50 and 70.
 
Malignant fibrous histiocytoma usually appears in the legs or the arms; however, cases of malignant fibrous histiocytoma have developed in the:
 
  • Abdomen
  • Lungs
  • Muscles
  • Kidneys.
     

Malignant Fibrous Histiocytoma: Causes and Risk Factors

No one knows the exact cause or causes of malignant fibrous histiocytoma; however, research has shown that people with certain malignant fibrous histiocytoma risk factors are more likely than others to develop the condition. A risk factor is anything that increases a person's chances of developing a disease.
 
 
  • Having previously undergone radiation treatment for cancer
  • Having a history of Paget's disease
  • Having a history of sickle cell disease, non-Hodgkin's lymphoma, Hodgkin's lymphoma, or multiple myeloma.
     
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Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD